keyword in microRNA or target gene :
The pre-miRNA of MI0000289
Gene
HGNC MIRN213
Accession no
MI0000289
ID
hsa-mir-181a-1
Species
Homo sapiens
Description
Homo sapiens miR-181a-1 stem-loop
Genomic Location
1 : 197094796 - 197094905 : -
View in the Genome Browser
Locate on gene exon/intron/UTR
intergenic
Pre-miRNA length
110 nt
Comments
Human miR-181a, cloned by Dostie et al [2], is predicted to be expressed from two genomic hairpin loci, hsa-mir-181a-1 (MIR:MI0000289) and hsa-mir-181a-2 (MIR:MI0000269). A miRNA from the 3' arm of this hairpin, named miR-213, was predicted by computational methods using conservation with mouse and Fugu rubripes sequences, and validated in zebrafish [1]. Subsequent cloning and Northern evidence shows that the 3' mature sequence is the biogenesis byproduct miR-181a* (Chang-Zheng Chen and David Bartel, pers. comm.).
2nd structure
[ pdf format ]
Get miRNA's sequence:
 
Related miRNAs
mmu-mir-181a-2 hsa-mir-181a-2 hsa-mir-181b-1 hsa-mir-181c hsa-mir-181a-1
hsa-mir-181b-2 mmu-mir-181a-1 mmu-mir-181b-1 mmu-mir-181c mmu-mir-181b-2
rno-mir-181c rno-mir-181a-2 rno-mir-181b-1 rno-mir-181b-2 rno-mir-181a-1
gga-mir-181a-1 gga-mir-181b-1 gga-mir-181b-2 gga-mir-181a-2 dre-mir-181b-1
dre-mir-181b-2 dre-mir-181a-1 dre-mir-181c ssc-mir-181b ssc-mir-181c
ggo-mir-181a-2 ppa-mir-181a-2 ptr-mir-181a-2 mml-mir-181a-2 sla-mir-181a-2
mne-mir-181a-2 mml-mir-181c ptr-mir-181c ggo-mir-181c ppa-mir-181c
mml-mir-181a-1 mml-mir-181b ptr-mir-181a-1 ptr-mir-181b ppy-mir-181a-1
ppy-mir-181b ggo-mir-181a-1 ggo-mir-181b lla-mir-181a-1 lla-mir-181b
mne-mir-181a-1 mne-mir-181b ppa-mir-181a-1 ppa-mir-181b hsa-mir-181d
fru-mir-181b-1 tni-mir-181b-1 fru-mir-181a-1 tni-mir-181a-1 fru-mir-181b-2
tni-mir-181b-2 tni-mir-181a-2 dre-mir-181a-2 fru-mir-181a-2 bta-mir-181a
xtr-mir-181b-1 xtr-mir-181b-2 xtr-mir-181a-1 xtr-mir-181a-2 bta-mir-181b
bta-mir-181c mdo-mir-181c mdo-mir-181a mdo-mir-181b mmu-mir-181d
The mature miRNA of MI0000289
Mature name
hsa-miR-181a
Mature sequence
24| 5'- AACAUUCAACGCUGUCGGUGAGU -3' |46
Tissue specificity
Bead-array microRNA expression profile
MicroRNA Expression Profiles Classify Human Cancers
  Nature 435, 834-838(9 June 2005)

QPCR microRNA expression profile

 

Target genes
ENST00000337907 (targeted by hsa-miR-181a, predicted by TargetScan)
Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein). [Source:Uniprot/SWISSPROT;Acc:Q9P2R6]
 
     
ENST00000377464 (targeted by hsa-miR-181a, predicted by TargetScan)
Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein). [Source:Uniprot/SWISSPROT;Acc:Q9P2R6]
 
     
ENST00000377083 (targeted by hsa-miR-181a, predicted by TargetScan)
Kinesin-like protein KIF1B (Klp). [Source:Uniprot/SWISSPROT;Acc:O60333]
 
     
   
 
The mature miRNA of MI0000289
Mature name
hsa-miR-181a*
Mature sequence
64| 5'- ACCAUCGACCGUUGAUUGUACC -3' |85
Target genes
ENST00000372915 (targeted by hsa-miR-181a*, predicted by TargetScan)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620). [Source:Uniprot/SWISSPROT;Acc:Q9UPN3]
 
     
ENST00000372915 (targeted by hsa-miR-181a*, predicted by TargetScan)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620). [Source:Uniprot/SWISSPROT;Acc:Q9UPN3]
 
     
ENST00000372736 (targeted by hsa-miR-181a*, predicted by TargetScan)
Collagen alpha-2(IX) chain precursor. [Source:Uniprot/SWISSPROT;Acc:Q14055]
 
     
   
 
The reference
Literature
1. "Vertebrate microRNA genes"
  Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP
  Science. 299:1540(2003).
2. "Numerous microRNPs in neuronal cells containing novel microRNAs"
  Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G
  RNA. 9:180-186(2003).
3. "New human and mouse microRNA genes found by homology search"
  Weber MJ
  FEBS J. 272:59-73(2005).
 

Department of Biological Science and Technology,
Institute of Bioinformatics National Chiao Tung University, Hsinchu, Taiwan
Contact with: bryan@mail.NCTU.edu.tw

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